Jacques Monod, François Jacob, and the Lysenko Affair: Boundary Work

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Enzymatic cybernetics: an unpublished work by Jacques Monod.

In 1959, Jacques Monod wrote a manuscript entitled Cybernétique enzymatique [Enzymatic cybernetics]. Never published, this unpublished manuscript presents a synthesis of how Monod interpreted enzymatic adaptation just before the publication of the famous papers of the 1960s on the operon. In addition, Monod offers an example of a philosophy of biology immersed in scientific investigation. Monod...

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Jacob and Monod: From Operons to EvoDevo

As Francois Jacob tells it, one afternoon in September 1958, just back from New York, he walked into Jacque Monod’s office at the Pasteur Institute in Paris; he believed he had something exciting to discuss. But he found an unimpressed Monod brusquely dismissive. Tired from his flight, Jacob quickly gave up and went home to bed. The next day he returned re-energized and found an altogether more...

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Jacques Monod, born 100 years ago, was one of the main founders of molecular biology. A quotation of Roger Stanier seems to me of immediate relevance to the topic of this meeting on ‘‘Chance and necessity in evolution,’’ dedicated to the works of Jacques Monod: ‘‘Jacques Monod, one of the great scientists of the twentieth century, will always have an honored place among the leaders of the secon...

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The same processes that permit cellular control of metabolism also provide the means of regulating how genes are expressed. At the metabolic level, cellular compounds bind to specific enzymatic proteins, changing their shape and therefore their function. At the level of mRNA synthesis, a similar series of allosteric controls (enzymes) exists, regulating which genes are transcribed and to what e...

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ژورنال

عنوان ژورنال: L'Esprit Créateur

سال: 2012

ISSN: 1931-0234

DOI: 10.1353/esp.2012.0020